How Cannabis Oil Suppositories Treatments Can Save Lives
There are many advantages to the rectal administration of cannabis oil not afforded by other routes. Medicine may still be administered even if the oral route is impaired (e.g., due to vomiting, an injured jaw or throat, or gastrointestinal difficulties) or disallowed due to the oral intake restrictions that are frequently required both before and after surgery. Avoiding the gastrointestinal tract also prevents first-pass metabolism by the stomach and liver, which break down many different molecules into their constituent parts (including Δ9-tetrahydrocannabinol, otherwise known as THC), and allows the active constituents to reach the blood in much higher concentrations.
In the case of THC, the liver transforms around half of what is ingested into the significantly more psychoactive metabolite 11-Hydroxy-Δ9-tetrahydrocannabinol This molecule causes much more intense cognitive effects than THC. One of the primary reasons our cannabis oil suppositories are so popular with our members, is that our rectal nigh time suppositories significantly diminish the side effects of delta-9-THC, mainly that notorious “high” feeling.. This increase in overall efficiency is also shown in the different levels of bioavailability that different administration routes afford, as seen in Fig. 1. Rectal administration also allows for medicine to exert effects over localized ailments (e.g. hemorrhoidal tissue, inflammation of the rectum, or tumors in the rectal cavity). This form of use also has a much faster uptake than oral administration (around 10 minutes, on average) and leads to more consistent blood concentrations of the active constituents. The speed and reliability of their uptake combined with their circumvention of many of the issues surrounding both ingestion and inhalation make rectal applications an excellent addition to both new and pre-existing therapeutic regimens.
Method of intake
Bioavailability of Cannabis: Routes
Comparative bioavailability of different administration routes
Inhalation: 10 – 25% efficiency, highly variable, depends largely on the individual’s level of experience
Oral: around 20% efficiency, highly variable, even between doses within a single individual
Rectal: around 50% – 70% efficiency, with predictable effects even between different individuals
When designing a personalized medication regimen, it is important to know the various timings involved with a given administration route. With MR-Series rectal administration, most people will begin to notice initial effects within the first 10 – 15 minutes after insertion. These effects usually last for between 4 – 8 hours, depending on the individual’s physiology and tolerance to cannabis oil. This swift increase in effect allows for acute dosing in many cases, although this depends both on the situation and on specific individual needs. There are several issues that can slow absorption from the rectum to the blood stream. Diarrhea and fecal matter can slow or prevent the active ingredients from reaching the rectal wall and being absorbed. Tumors or cysts on the rectal wall can also slow or prevent absorption. In this case, less medicine would reach the blood, but as the tumors are likely the intended target(s) of the rectal administration, the direct delivery of the active constituents may help prevent an overall reduction in efficacy. Finally, rectal dehydration can drastically reduce the effectiveness of treatments. Staying well hydrated by maintaining a healthy consumption of both water and electrolytes should prevent this in most cases, but specific medical conditions may cause it as well, in which case the solution may not be as simple. As always, if there are concerns, a medical professional should be consulted.
Facilitating Families Requiring Medicinal Cannabis Oil Worldwide
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